SIRTUINS (“Guardians of the Genome”) are NAD+ dependent lysine deacylases that promote longevity & healthy ageing.
How to modulate SIRTUINS?
STACs (sirtuin-activating compounds like resveratrol works like an accelerator) and increasing NAD+ levels (with precursors like NMN which acts like fuel) improve metabolic function and increase lifespan.
What are the ultimate bio-hacks to increase youngevity healthspan?
Hormesis (Good stress that boost your resilience) through calorie restriction, intermittent & extended fasting, fasting mimicking diet, polyphenols( xenohormetins like resveratrol ), intermittent heat and cold exposure( infrared sauna & cold showers/plunges) & exercise(HIITS)
Autophagy (self repair) through prolonged fasting & physical exercise.
Ischemic preconditioning (oxygen deprivation) through breath-control techniques (yoga)
Moderate calorie restriction with diet rich in proteins & micronutrients(minerals, vitamins, antioxidants, polyphenols etc.,)
Social contribution, Spiritual connection , Gratitude & Kayakalpam.
HORMESIS GOVERNS A PLEIOTROPIC PRO-SURVIVAL PROGRAM
When exposed to mild stress, cells/organisms respond by a variety of adaptive cellular programs that procure a preconditioned state.
When an intense stress is applied subsequently, preconditioned but not naïve cells/organisms exhibit stress resistance and eventually improved survival.
